Can You Have Allergic Reaction to CBD Oil?

CBD is considered the 2nd most popular cannabinoid that is derived from the cannabis plant. CBD oil, which is extracted from industrial hemp or marijuana, has obtained its popularity for its potential benefits for several conditions.

In fact, CBD can alleviate chronic and acute pains, fight inflammation and insomnia, and manage anxiety and stress. Other studies on CBD [1] have also shown that it possesses anti-histamine properties that offer relief from sneezing, nasal blockage, and allergic reaction to dust mites, animal hair or dander, and even pollen.

But it is also worth mentioning that one may also experience some side effects of consuming a hemp extract even though it is of good quality and laboratory tested. Some of the common side effects that you may experience include:

  • Nausea (rare)
  • Fatigue
  • Drowsiness
  • Loss of weight or appetite
  • Diarrhea (rare)
  • Dry mouth
  • Low blood pressure
  • Lightheadedness

One of the most debated topics on the internet these days is “can you have an allergic reaction to CBD oil?”

According to some studies [2,3], CBD oil particularly when given topically may help with various types of allergies such as seasonal rashes, toxic reaction to pollen and food, and bug bites.

But the question is, is it possible that you will experience an allergic reaction to CBD? Would you like to know that answer? If yes, then keep on reading.

Allergic Reactions to CBD Oil

People usually experience an allergic reaction to several types of plant pollen. But, keep in mind that only male hemp plants or cannabis give off pollen while the female pollen is widely utilized for cannabinoid and oil production.

On the other hand, big- industrial hemp fields might include a wide variety of mature pollens and fertilized females. However, the effect of hemp pollen on a day-to-day consumer and communities that work as well as living near the production facilities hasn’t been studied.

Further, allergies may develop to a number of terpenes usually seen in hemp or cannabis. Researchers [4] found that approximately 20 percent of people have allergic skin reactions to linalool while 8 percent of people have a reaction to limonene. However, such types of contact allergies may not take place in day-to-day consumers of hemp or cannabis. But, those who are working in the production of CBD oil and cannabis products may be more susceptible.

Aside from skin sensitivity, another target for an allergic reaction to terpenes is the lungs. However, the story is somewhat tricky since some terpenes are considered irritants while others like eucalyptol can really offer an anti-inflammatory and protective role. Not only that, but it may also help in controlling anti-inflammatory diseases such as COPD and asthma.

Further, usually, it has been perceived that those who are otherwise allergic to common allergens [5] including plants, cat dander, molds, and dust mites are more susceptible to wee allergy. Though there are times that one has to smoke it to show allergic reactions. Simply inhaling pollen and having direct contact with the plant may trigger these reactions.

Signs of Cannabis Allergy


For the first couple of uses, while users of CBD may experience a headache, a migraine is a symptom of something more stringent.

Red, Dry, or Itchy Eyes

We all know that weeds are well-known for causing red-eye as an outcome of dryness. However, it is worth mentioning that CBD is not the real culprit but THC. Some CBD users may experience it after consuming CBD. But if you experience bloodshot or excessive watering eyes it may an allergic reaction instead of a side effect.

Respiratory Issues

If you are having a hard time breathing, we highly recommend that you consult a medical professional right away.

With a CBD product, breathing problems are likely to be the common outcome of poor-quality items that consist of contaminants from hemp plants like mold and pollen.

However, aside from the above-mentioned, some signs of cannabis allergy include:

  • Nausea
  • Sneezing
  • Running nose
  • Throat congestion
  • Skin irritation
  • Hives
  • Blisters
  • Dry Skin
  • Inflammation and redness of the skin


A rare, but severe form of an allergic reaction to CBD oil is a condition called anaphylaxis. It is worth mentioning that this condition may become deadly within a few seconds of coming in contact with plant extracts or the plant itself.

Some of the most common signs of anaphylaxis are as follow:

  • Pale skin
  • Itchy skin
  • Feeling dizzy
  • Loss of consciousness
  • Can’t see clearly
  • Can’t breathe
  • Weak pulse rate
  • Vomiting

Keep in mind that an anaphylactic shock may bring someone to a coma or worse kill the person. So you need to be very mindful.

Other Signs That You Are Allergic to Cannabis

There is a huge possibility that you might not know you are allergic to cannabis. But if you have experienced allergic reactions to the food we will be mentioning below then you are likely to experience from similar signs when making contact with cannabis.

  • Tomato
  • Almond
  • Banana
  • Chestnut
  • Apple
  • Grapefruit
  • Eggplant and Peach

One reason for that is that such foods share the same protein formation as marijuana [6, 7].

Can Be A Person Allergic to CBD Oil?

We are pretty sure that the vast majority of people are concerned about this. Unfortunately, it is possible for a person to have an allergic reaction to CBD oil.

Nevertheless, if you want to find out whether you are allergic to CBD or not, it is recommended that you know the properties of its components.

Full-spectrum CBD oil consists of different cannabinoids like CBD, THC, fatty acids, flavonoids, terpenes, as well as hemp seed oil. However, to determine the effects of the CBD, you need to be aware of the effects of these components.

For CBD oils with broad-spectrum, you may forget about the effects of THCs since they are eliminated from the equation. But for products that have CBD isolates, you do not need to worry about the ingredients except CBD.

Let’s go back to the full-spectrum CBD oil. Have you heard about the entourage effect? If not, well it is one of the main reasons why most people are ardent to try out CBD since they deem that they will be able to obtain synergistic benefits of all such components. As a matter of fact, most of them have been autonomously found to beneficial for the mind and body.

For you to understand it better, let’s take a look at the different types of cannabis oils along with allergy profiles.

Full-Spectrum CBD Oil and Its Allergy Profile

It is true that some people who used full-spectrum CBD oil felt a healthy experience. However, it is worth mentioning that some suffered from an allergic reaction after using the said product. This is because it consists of 0.3 percent of THC.

Despite the fact that terpenes can offer a lot of therapeutic advantages they might be also accountable for the allergic reactions individuals have experienced when they use full-spectrum CBD oil.

When it comes to the hemp soil that is often utilized as the carrier oil while creating CBD oil, individuals have found out that it is beneficial. But those who are experiencing marijuana allergies will show the same allergic reactions to the component.

What’s more, those who are sensitive to plant extracts or plants typically experience these reactions to either hemp extract or marijuana too.

CBD Isolate and its Allergy Profile

Unless you consume a large amount of CBD all at once, usually, CBD, as well as other non-psychoactive ingredients, don’t pose any threat to people.

While CBD alone has a safety and better profile, combining it with other carrier oils that are extracted from cannabis oil can have the same effects if you are sensitive to these plants. For example, MCT, hemp seed oil, or olive oil that is a subsidiary of coconut oil. However, even though coconut oil isn’t extracted from nuts or seeds, still, it may pose the same effects, most especially if you are sensitive to it.

On the other hand, as mentioned earlier, consuming CBD in large amounts may trigger serious effects including dry mouth, low blood pressure, drowsiness, nausea, add light-headedness. You need to fully understand that CBD is considered a chemical compound. And take note, chemical compounds of any kind place in one’s body may cause undesirable effects.

With this in mind, we highly recommend that you should limit exposing your body to new chemicals. Or if possible, consult a medical expert before doing so.

Hemp Seed Oil and Its Allergy Profile

The majority of research studies conducted on cannabis mostly focused on THC and at the same time cannabis without too many details regarding hemp oil available. But regardless of this fact, always remember that hemp causes allergic reaction the same to what is acknowledged as cannabis allergies since it consists of a similar protein.

Histamines: The Thing That Makes You Sensitive to CBD

If you’re wondering what makes you sensitive to CBD, the real culprit is histamines – these are hormones concealed by the body’s pole cells and are dispersed all throughout the body.

Once the pole cells sense foreign entities in the system, it will repel them by stashing histamines. This will trigger a variety of allergic reactions in the body such as:

  • Dizziness
  • Watery eyes
  • Inflammation
  • Coughing
  • Rashes

CBD Oil Interaction with Medication

Most of the time, CBD oil doesn’t interact with a prescription drug. However, once it does, it might cause mild as well severe side effects which may lead to fatal consequences.

With that in mind, it is best that you should not take any medication while you are consuming CBD oil before you consult a medical expert. In some instances, you might be strained to either stick to the prescription drug and stop CBD or only stick to CBD.

Nevertheless, some of the medications that interact with CBD oil are the following:

  • Antidepressant
  • Antipsychotics
  • Anesthetic
  • Antiarrhythmics
  • Immune modulators
  • Antihistamines
  • Beta-blockers
  • Steroids and
  • Benzodiazepines

If you’re not certain what should you do when it comes to medicine intake, we recommend that you seek assistance from experts such as a doctor, a pharmacist, and even a CBD professional.

Final Words

As a safety precaution, if you are suffering from any type of allergy, you need to be very careful when consuming CBD oil. Better yet, opt for a CBD isolate because as mentioned earlier, this form of CBD has lower chances of initiating allergic reactions.

However, if you’re utilizing an isolate to create your tincture and vape juice, you need to stay away from ingredients you may be sensitive to. On the other hand, if you are allergic to certain plant extracts, it is best that you create your CBD oil from the comfort of your own home.

Another great way to alleviate allergic reactions to CBD is to purchase products from high-quality and reliable brands. As a matter of fact, the majority of problems appear to root from unwanted plant matter ending up in the finish products. Take note, this is going to happen with dishonest manufacturers.

When making a purchase, check the lab reports of the product you are considering in order to determine that there’s no contaminant.

Keep in mind that, spending to a high-quality even though it may cost you more is worth considering.

Nevertheless, if you’re not sure whether you have an allergy or not, it is best that you consult your doctor first before consuming CBD oil because allergies can be very annoying to deal with most especially when it’s something that will impede your everyday life.

We hope that you have learned a lot from this post.

Research Citations [n]:

  1. Cannabinoid Delivery Systems for Pain and Inflammation Treatment; Molecules; September 27, 2018; Natascia Bruni, Carlo Della Pepa, Simonetta Oliaro-Bosso, Enrica Pessione, Daniela Gastaldi, and Franco Dosio;
  2. A therapeutic effect of CBD-enriched ointment in inflammatory skin diseases and cutaneous scars; Clinical Therapeutics; March-April 2019; Palmieri B, Laurino C, Vadalà M;
  3. Cannabinoids in dermatology: a scoping review; Dermatology Online Journal; June 15, 2018; Eagleston LRM, Kalani NK, Patel RR, Flaten HK, Dunnick CA, Dellavalle RP;
  4. Contact Allergy to Hydroperoxide of Linalool and D-limonene in a US Population; October 28, 2017; Dermatitis; Nath NS, Liu B, Green C, Atwater AR;
  5. Marijuana use is associated with hypersensitivity to multiple allergens in US adults; Drug and Alcohol Dependence; Volume 182, 1 January 2018, Pages 74-77; Jin-YoungMina & Kyoung-BokMin;
  6. New food allergies in a European non-Mediterranean region: is Cannabis sativa to blame? International Archives of Allergy & Immunology; Mar 15, 2013; Ebo DG, Swerts S, Sabato V, Hagendorens MM, Bridts CH, Jorens PG, De Clerck LS;
  7. Sensitization and allergy to Cannabis sativa leaves in a population of tomato (Lycopersicon esculentum)-sensitized patients; International Archives of Allergy & Immunology; Feb 11, 2008; de Larramendi CH, Carnés J, García-Abujeta JL, García-Endrino A, Muñoz-Palomino E, Huertas AJ, Fernández-Caldas E, Ferrer A;

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